ASE Funded Research – Project Summaries
2009 ASE Cardiovascular Sonographer Research Award Recipient
Echocardiographic Assessment of Hypertrophic Cardiomyopathy Induced by Overexpression of C-Myc
2009 ASE Echo Investigator Award Recipient
Determining the Genetics of Atherosclerosis Using a Vascular Ultrasound Phenotype
2009 ASE Echo Investigator Award RecipientPolymer Injection Therapy for Treatment of Ischemic Mitral Regurgitation
Judy Hung, Orhun Muratoglu, Gavin Braithwaite. Massachusetts General Hospital, Boston, MA
2008 ASE Career Development Award Recipient
Combined Usefulness of Doppler Myocardial Imaging, Cardiac Biomarkers, and Cardiac Magnetic Resonance for Early Diagnosis of Cardiac Involvement and Risk Stratification in Patients with Systemic AL Amyloidosis
2008 ASE Career Development Award Recipient & 2009 Arthur E. Weyman Young Investigator’s Award Competition Finalist
Mitral Valve Leaflet Area Quantification: A 3D Echo-Histology Study of Mitral Valve Adaptation in Ischemic Mitral Regurgitation
2008 ASE Career Development Award Recipient
Molecular Imaging of Stem Cell Therapy Using Targeting Contrast Ultrasound
Hiroko Fujii1, Jonathan Lindner2, Howard Leong-Poi1. 1St. Michael’s Hospital, Toronto, ON, Canada; 2Oregon Health & Science University, Portland, OR
2008 ASE Career Development Award Recipient
Contrast Ultrasound for Quantification of Plaque Neovascularization: A New Method to Identify Vulnerable Plaque
2. Molecular imaging of VV by targeted CUS will specifically delineate pathologic neovascularization.
3. Therapies to target angiogenesis can reverse or attenuate the progression of neovascularization, while decreasing plaque burden.
2008 ASE Cardiovascular Sonographer Research Award Recipient
The Effect of Right Ventricular Pacing Site on Measures of Mechanical Ventricular Dyssynchrony
2. Evaluating three-dimensional dyssynchrony indices; and,
3. Determining which pacing location provides the most synchronous RV and LV contraction.
2008 ASE Cardiovascular Sonographer Research Award Recipient
Pulmonary Response by Echocardiography: The PURE Study
ii) Apply the variables from Aim 1 in a longitudinal study of PAH patients to determine which are most highly predictive of invasive hemodynamics and clinical outcomes;
iii) Based on the findings of Aims 1-2, a recommendation for standardization of echocardiographic assessment and analysis for patients with known or suspect PAH will be developed.
2008 ASE Echo Investigator Award Recipient
Preload Recruitable Stroke Work derived from Three Dimensional Echocardiographic Pressure: Volume Loop Analysis in Congenital and Pediatric Heart Disease
2008 ASE Echo Investigator Award Recipient
Comprehensive Evaluation of the Systemic Right Ventricle by Two-Dimensional Strain Echocardiography in Patients with D-Transposition of the Great Arteries: Impact on Outcomes
2007 ASE Career Development Award Recipient
Mechanisms of Diastolic Heart Failure after Myocardial Infarction: Relationship Between Extent of Myocardial Scarring, Infarct Location and Left Ventricular Relaxation and Stiffness
2007 ASE Career Development Award Recipient
Cardiac Structure, Function, and Exercise Capacity in Competitive Athletes: A Prospective, Longitudinal Investigation of Endurance Athletes
2007 ASE Career Development Award Recipient
Echo-Genomics: Identification of the Genetic Determinants of Left Ventricular Hypertrophy and its Pathophysiologic Consequences
2. Prospectively validate the association of genetic polymorphisms (identified in the Hutterites) with LV mass in the Chicago Echo-Genetics Study.
3. Test whether genetic polymorphisms identified in the Hutterites have an effect on tissue velocity, strain, and torsion in the Chicago Echo-Genetics Study.
2007 ASE Career Development Award Recipient
Effect of Cardiac Resynchronization Therapy on Mitral Valve Geometry and LV Spatial Relationships
2007 ASE Career Development Award Recipient
Meta-Analysis Research Group in Echocardiography (MeRGE) Sub Analyses
Gillian Whalley1, Robert Doughty1, Allan Klein2. 1University of Auckland, Auckland, New Zealand; 2Cleveland Clinic Foundation, Cleveland, OH
2007 ASE Cardiovascular Sonographer Research Award Recipient
A Standardized Technician Facilitated Protocol for use in V-V Optimization of Biventricular Pacemakers for Cardiac Resynchronization Therapy
2007 ASE Cardiovascular Sonographer Research Award Recipient
Functional Measurements of Heart Failure and Clinical Outcomes after Cardiac Resynchronization Therapy: Correlation with Echocardiographic-derived Indices of Left Ventricular Function
2. To determine whether functional measurements of HF severity and/or echocardiographic indices of LV function, at baseline and at early follow-up, are predictive of clinical outcomes (i.e., re-hospitalization for HF and/or cardiac related death or transplant) at long-term follow-up after CRT.
2007 ASE Echo Investigator Award Recipient
Correlation Between Changes in Functional Mitral Regurgitation and Diastolic Dysfunction and Changes in BNP Level and Wall Stress During Hospitalization for Heart Failure and their Significance in Predicting Outcome
Karthikeyan Ananthasubramaniam, Moham Abu-Mahfouz, Mohsin Alam, David Lanfear, James McCord, John Schairer. Henry Ford Hospital, Detroit, MI
2007 ASE Echo Investigator Award Recipient
Real-Time Three Dimensional Echocardiographic Quantification of Myocardial Perfusion
Victor Mor-Avi1, Enrico Caiani2, Patrick Coon1, Elizabeth Holper1, Roberto Lang1. 1University of Chicago, Chicago, IL; 2Politecnico di Milano, Milan, Italy